MTHFR, Methylation, and Weight Loss Resistance: What the Science Truly Shows
Examining C677T and A1298C variants in the MTHFR gene. Separating clinical facts from online wellness myths regarding homocysteine, energy production, and fat metabolism.
Few genetic topics generate as much online confusion as the MTHFR gene. We examine what the biochemical literature actually demonstrates regarding folate metabolism, mitochondrial ATP synthesis, and cellular fat oxidation.
The Biochemical 1-Carbon Cycle
MTHFR catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF), the active cosubstrate necessary to remethylate toxic homocysteine back to methionine. When enzyme efficiency is lowered due to homozygous 677TT status, intracellular glutathione generation and carnitine biosynthesis can be modestly affected.
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